Goss had rocketed into the yellow leader's jersey on stage three after avoiding several fallen riders and outsprinting Heinrich Haussler (Garmin-Cervelo) and Denis Galimzyanov (Katusha).
Stage four was a different story however, with Goss forced to the back of the peloton with cramps.
"Terrible stomach today unfortunately," the 24-year-old said on his Twitter account post-stage. "Cramps and unable to eat for the last 80k. Not good when u have 3000m of climbing to get through."
Goss finished today's 191km stage back in 117th position, 13 seconds behind winner, French champion Thomas Voeckler (Europcar), pushing the Australian back to fourth overall, 21 seconds down on leader Thomas De Gendt (Vacansoleil-DCM).
The effort of Goss to stay in sight of the yellow jersey was not lost on compatriot Richie Porte of Saxo Bank Sungard, who tweeted: "Chapeu @mattgoss1986 for great ride under the circumstances."
Goss had targeted the opening three stages of the Paris-Nice for a stage win and the possibility of the yellow leader's jersey. With the race now headed for the hills towards Nice, the Australian's focus will shift again.
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"In the mountainous stages it'll be a question of working for the team's GC guys and getting good form for the Classics," Goss said prior to the event.
Tony Martin and Tejay Van Garderen are next-best for HTC-Highroad, 37 seconds behind De Gendt, with the pair expected to play their cards in Friday's time trial.
As a sports journalist and producer since 1997, Jane has covered Olympic and Commonwealth Games, rugby league, motorsport, cricket, surfing, triathlon, rugby union, and golf for print, radio, television and online. However her enduring passion has been cycling.
Jane is a former Australian Editor of Cyclingnews from 2011 to 2013 and continues to freelance within the cycling industry.
