IOC chief interested in how EPO changes cells for long periods
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A message denouncing French rider Richard Virenque doping was painted on the prologue course in Le Puy du Fou in the 1999 Tour de France after the previous year's Festina scandal.(Image credit: AFP Photo)
A Tour de France fan states his case for cessation of doping in the professional peloton(Image credit: AFP)
One of Spain’s most renowned cancer specialists has revealed how investigations into what encourages certain cancers to develop in the human body could be used to detect doping by athletes. Speaking at a conference entitled "Looking for new elements for the detection of doping within sport" that has been taking place at the headquarters of the Spanish Olympic Committee in Madrid, Dr Cristóbal Belda-Iniesta explained how "there are substances that degrade in hours and can therefore be practically undetectable, but which leave a footprint in genetic memory that can be detected five years later".
Dr. Belda, head of thoracic oncology and neuro-oncology at HM Hospitals in Madrid and a professor at the University of San Pablo CEU, is currently overseeing a project studying new ways to detect evidence of doping. Next month, new International Olympic Committee president Thomas Bach will head to Madrid for a presentation of this research, which could be introduced into anti-doping campaigns to run alongside existing drug testing procedures.
Dr. Belda and his research team have built up significant knowledge of how a variety of products that are used as part of cancer treatments, including EPO, growth hormone and IGF-1, can change the make-up of cells. "All these substances are very well known to cells, and therefore to me," said Belda, who came to prominence in Spain as oncologist to the late golfing great Severiano Ballesteros.
"Indeed, tumour cells feed off EPO and because of that they develop specific receptors. For that reason, we know all about EPO and we are learning how to fight that as part of the battle against cancer," El País reported Dr. Belda as saying. He added that even a tiny drop of EPO can boost the size of a tumor cell culture by "1,800 in just five days when normally, without EPO, it would double in size at most over the same period."
Dr. Belda also outlined the dangers of some these products when it comes to a user's long-term health. "It can be affirmed that doping substances like these are substances that can be used experimentally in a laboratory to produce cancers and cardiovascular illnesses. They are substances that help to create cancer.
"I have said experimentally because there are no epidemiological studies to back this up. But the scientific basis for this is simple: each cell has needed millions of years to evolve and reach a perfect state. When we modify it in an accelerated way with one of these substances we modify all of them, because they are all connected. For this reason, I want to fight against doping because it is a health issue."
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Peter Cossins has written about professional cycling since 1993 and is a contributing editor to Procycling. He is the author of The Monuments: The Grit and the Glory of Cycling's Greatest One-Day Races (Bloomsbury, March 2014) and has translated Christophe Bassons' autobiography, A Clean Break (Bloomsbury, July 2014).
